Science to practice: can macrophage infiltration serve as a surrogate marker for stem cell viability?

Radiology. 2012 Sep;264(3):619-20. doi: 10.1148/radiol.12121378.

Abstract

Following in vivo prelabeling of host macrophages with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles, it was shown that their magnetic resonance (MR) imaging–visible migration into knee implants of scaffolded adipose-derived stem cells (ADSCs) undergoing apoptosis can serve as a surrogate marker of stem cell death.

MeSH terms

  • Adipose Tissue / cytology
  • Animals
  • Apoptosis
  • Biomarkers
  • Cell Survival
  • Contrast Media / metabolism
  • Dextrans / metabolism*
  • Humans
  • Knee Injuries / therapy
  • Macrophage Activation*
  • Macrophages / metabolism*
  • Magnetic Resonance Imaging*
  • Magnetite Nanoparticles
  • Nanoparticles
  • Stem Cell Transplantation*
  • Tissue Engineering / methods
  • Tissue Scaffolds

Substances

  • Biomarkers
  • Contrast Media
  • Dextrans
  • Magnetite Nanoparticles
  • ferumoxides