Drug interactions with the dietary fiber Plantago ovata husk

Expert Opin Drug Metab Toxicol. 2012 Nov;8(11):1377-86. doi: 10.1517/17425255.2012.716038. Epub 2012 Aug 27.


Introduction: Plantago ovata husk is a viscous water-soluble fiber obtained by milling the seed of Plantago ovata. The increased use of this compound for the treatment of diseases makes it necessary to know of its potential drug interactions.

Areas covered: The present paper reviews the literature concerning interactions between drugs and the dietary fiber Plantago ovata husk. All publications which might describe interactions between the dietetic fiber Plantago ovata husk and other drugs were identified by searches using databases such as MEDLINE or EMBASE.

Expert opinion: Drug interactions have been the subject of numerous studies, but few of them have been carried out with dietary fiber and the results obtained have often been variable. The incidence and importance of interactions between fiber and drugs has increased due to a worldwide rise in the use of dietary fiber. Plantago ovata husk has the potential for producing both benefits and risks with both desirable and undesirable effects when coadministered with drugs. More clinical studies are justifiably needed to improve treatments and to better evaluate patient safety.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Availability
  • Dietary Fiber / administration & dosage*
  • Digoxin / blood
  • Drug Interactions*
  • Humans
  • Levodopa / administration & dosage
  • Lithium / blood
  • Models, Animal
  • Plantago / chemistry*
  • Seeds / chemistry
  • Thyroxine / blood


  • Dietary Fiber
  • Levodopa
  • Digoxin
  • Lithium
  • Thyroxine