Increased risk of acute hepatitis B among adults with diagnosed diabetes mellitus

J Diabetes Sci Technol. 2012 Jul 1;6(4):858-66. doi: 10.1177/193229681200600417.


Introduction: The risk of acute hepatitis B among adults with diabetes mellitus is unknown. We investigated the association between diagnosed diabetes and acute hepatitis B.

Methods: Confirmed acute hepatitis B cases were reported in 2009-2010 to eight Emerging Infections Program (EIP) sites; diagnosed diabetes status was determined. Behavioral Risk Factor Surveillance System respondents residing in EIP sites comprised the comparison group. Odds ratios (ORs) comparing acute hepatitis B among adults with diagnosed diabetes versus without diagnosed diabetes were determined by multivariate logistic regression, adjusting for age, sex, and race/ethnicity, and stratified by the presence or absence of risk behaviors for hepatitis B virus (HBV) infection.

Results: During 2009-2010, EIP sites reported 865 eligible acute hepatitis B cases among persons aged ≥23 years; 95 (11.0%) had diagnosed diabetes. Comparison group diabetes prevalence was 9.1%. Among adults without hepatitis B risk behaviors and with reported diabetes status, the OR for acute hepatitis B comparing adults with and without diabetes was 1.9 (95% confidence interval [CI] = 1.4, 2.6); ORs for adults ages 23-59 and ≥60 years were 2.1 (95% CI = 1.6, 2.8) and 1.5 (95% = CI 0.9, 2.5), respectively.

Conclusions: Diabetes was independently associated with an increased risk for acute hepatitis B among adults without HBV risk behaviors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Disease
  • Adult
  • Aged
  • Aged, 80 and over
  • Diabetes Complications / epidemiology
  • Diabetes Complications / ethnology
  • Diabetes Mellitus / diagnosis
  • Diabetes Mellitus / epidemiology*
  • Diabetes Mellitus / ethnology
  • Female
  • Hepatitis B / epidemiology*
  • Hepatitis B / ethnology
  • Hepatitis B / etiology*
  • Humans
  • Male
  • Middle Aged
  • Population Surveillance
  • Prevalence
  • Risk Factors
  • Young Adult