[Calcium signaling in T lymphocytes]

Med Sci (Paris). Aug-Sep 2012;28(8-9):773-9. doi: 10.1051/medsci/2012288020. Epub 2012 Aug 22.
[Article in French]

Abstract

Calcium signaling is essential for all the functions of T lymphocytes, including those of Th2 cells. Th2 lymphocytes producing interleukins 4, 5 and 13 orchestrate allergic diseases including asthma. T-cell activation induces an influx of Ca(2+) from the external medium through ORAI calcium channels although other calcium channels are likely to be involved. Among them, voltage-gated calcium (Ca(v)1) channels have been reported in some T-cell subsets including Th2 cells. The inhibition of Ca(v)1 channels abrogates T-cell receptor-driven calcium influx and interleukin production by Th2 cells. From a therapeutic point of view, the inhibition of Ca(v)1 channels prevents Th2-dependent experimental allergic asthma. In this review, we will discuss the singularities of calcium responses depending upon the T-cell subset and its state of activation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Asthma / drug therapy
  • Asthma / immunology
  • Asthma / physiopathology
  • Calcium Channel Blockers / pharmacology
  • Calcium Channel Blockers / therapeutic use
  • Calcium Channels / deficiency
  • Calcium Channels / drug effects
  • Calcium Channels / physiology*
  • Calcium Channels, L-Type / drug effects
  • Calcium Channels, L-Type / physiology
  • Calcium Signaling* / drug effects
  • Calcium Signaling* / physiology
  • Cell Compartmentation
  • Humans
  • Hypersensitivity / drug therapy
  • Hypersensitivity / immunology
  • Hypersensitivity / physiopathology
  • Interleukins / metabolism
  • Membrane Glycoproteins / deficiency
  • Membrane Proteins / physiology
  • Mice
  • Mice, Knockout
  • Models, Immunological
  • Neoplasm Proteins / physiology
  • ORAI1 Protein
  • Receptor-Interacting Protein Serine-Threonine Kinases / physiology
  • Stromal Interaction Molecule 1
  • T-Lymphocyte Subsets / drug effects
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / physiology*
  • Th2 Cells / drug effects
  • Th2 Cells / immunology
  • Th2 Cells / physiology

Substances

  • Calcium Channel Blockers
  • Calcium Channels
  • Calcium Channels, L-Type
  • Interleukins
  • Membrane Glycoproteins
  • Membrane Proteins
  • Neoplasm Proteins
  • ORAI1 Protein
  • ORAI1 protein, human
  • Orai1 protein, mouse
  • STIM1 protein, human
  • Stim1 protein, mouse
  • Stromal Interaction Molecule 1
  • RIPK3 protein, human
  • Receptor-Interacting Protein Serine-Threonine Kinases