New abietane norditerpenoid from Salvia miltiorrhiza with cytotoxic activities

J Asian Nat Prod Res. 2012;14(9):913-7. doi: 10.1080/10286020.2012.699962. Epub 2012 Aug 28.

Abstract

One new abietane-type norditerpenoid, named militibetin A (1), was isolated from the dry roots of Salvia miltiorrhiza, along with two known diterpenoids, yunnannin A (2) and ferruginol (3). Their structures were established by means of extensive spectroscopic analyses. In vitro, compounds 1-3 were found to show cytotoxicities against selected cancer cells, including P-388, HONE-1, and HT-29, and gave ED(50) values in the range of 2.9-5.4 μg ml(- 1).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abietanes / chemistry
  • Abietanes / isolation & purification*
  • Abietanes / pharmacology*
  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Drug Screening Assays, Antitumor
  • HT29 Cells
  • Humans
  • Leukemia P388
  • Mice
  • Molecular Structure
  • Plant Roots / chemistry
  • Salvia miltiorrhiza / chemistry*

Substances

  • Abietanes
  • Antineoplastic Agents, Phytogenic
  • ferruginol
  • militibetin A