Two new natural azafluorene alkaloids and a cytotoxic aporphine alkaloid from Polyalthia longifolia

J Nat Prod. 1990 Sep-Oct;53(5):1327-31. doi: 10.1021/np50071a028.

Abstract

The stem and stem bark of Polyalthia longifolia afforded the cytotoxic aporphine alkaloid liriodenine [1], as well as two aporphine alkaloids, noroliveroline [2] and oliveroline-beta-N-oxide [3] and three azafluorene alkaloids, darienine [4], polyfothine [6], and isooncodine [7], which are not bioactive. Polyfothine [6] and isooncodine [7] are new natural compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Aporphines / chemistry
  • Aporphines / isolation & purification
  • Aporphines / pharmacology*
  • Drug Screening Assays, Antitumor
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plants / analysis*

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Aporphines
  • polyfothine
  • darienine
  • isooncodine
  • liriodenine