Influence of drugs on vitamin D and calcium metabolism

Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.


In the past, interactions between drugs and vitamin D have received only little or no attention in the health care practices. However, since more and more drugs are used for the treatment of patients, this topic is increasingly relevant. Several drugs can interfere with the vitamin D and bone metabolism. Drugs that activate the pregnane X receptor can disrupt vitamin D metabolism and vitamin D function. Beside this, the medication oriented supplementation of vitamin D can ameliorate the pharmacologic action of some drugs, such as bisphosphonates, cytostatics and statins.

Keywords: 1,25-dihydroxyvitamin D [1,25(OH)2D]; 25-hydroxy-vitamin D [25(OH)D]; bisphosphonates; cytostatics; drugs; pregnane X receptor; statins; vitamin D.