Dietary chlorophyll metabolites catalyze the photoreduction of plasma ubiquinone

Photochem Photobiol. Mar-Apr 2013;89(2):310-3. doi: 10.1111/j.1751-1097.2012.01230.x. Epub 2012 Sep 26.

Abstract

Ubiquinol is a plasma antioxidant. The mechanisms responsible for maintenance of plasma ubiquinol are poorly understood. Here, we show that metabolites of chlorophyll can be found in blood plasma of animals that are given a chlorophyll-rich diet. We also show that these metabolites catalyze the reduction of plasma ubiquinone to ubiquinol in the presence of ambient light, in vitro. We propose that dietary chlorophyll or its metabolites, together with light exposure, regulate plasma redox status through maintaining the ubiquinol pool.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animal Feed
  • Animals
  • Biocatalysis / radiation effects
  • Cattle
  • Chlorophyll / chemistry
  • Chlorophyll / metabolism*
  • Chromatography, High Pressure Liquid
  • Humans
  • Light
  • Lipid Peroxidation / radiation effects
  • Mice
  • Oxidation-Reduction
  • Photolysis
  • Spectrometry, Fluorescence
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / blood*

Substances

  • Ubiquinone
  • Chlorophyll
  • ubiquinol