A role for vimentin in Crohn disease

Autophagy. 2012 Nov;8(11):1695-6. doi: 10.4161/auto.21690. Epub 2012 Aug 28.


Crohn disease (CD), one of the major chronic inflammatory bowel diseases, occurs anywhere in the gastrointestinal tract with discontinuous transmural inflammation. A number of studies have now demonstrated that genetic predisposition, environmental influences and a dysregulated immune response to the intestinal microflora are involved. Major CD susceptibility pathways uncovered through genome-wide association studies strongly implicate the innate immune response (NOD2), in addition to the more specific acquired T cell response (IL23R, ICOSLG) and autophagy (ATG16L1, IRGM). Examination of the disease-associated microbiome, although complex, has identified several potentially contributory microorganisms, most notably adherent-invasive E.coli strains (AIEC), which have been isolated by independent investigators in both adult and pediatric CD patients. Here we discuss our recent finding that the type-III intermediate filament (IF) protein VIM/vimentin is a novel NOD2 interacting protein that regulates NOD2 activities including inflammatory NFKB1 signaling, autophagy and bacterial handling.

Keywords: AIEC; Crohn disease; NOD2; autophagy; vimentin.

MeSH terms

  • Autophagy
  • Crohn Disease / metabolism*
  • Crohn Disease / microbiology
  • Crohn Disease / pathology*
  • Escherichia coli
  • Humans
  • Models, Biological
  • Nod2 Signaling Adaptor Protein / metabolism
  • Signal Transduction
  • Vimentin / metabolism*


  • Nod2 Signaling Adaptor Protein
  • Vimentin