Software for empirical building of biokinetic models for normal and decorporation-affected data

Health Phys. 2012 Oct;103(4):484-94. doi: 10.1097/HP.0b013e318265e0c3.

Abstract

This paper describes software ("RATDOSE") developed to analyze data from animal experiments investigating the efficacy of chelating agents. An empirical model building approach is used where, starting from the simplest model structures, one minimizes χ(2) by varying transfer rates in the model. Model complexity is increased as needed until the minimum attained value of χ(2) per data point decreases to about 1. This approach requires careful treatment of data uncertainties and independent checks of data self-consistency. The biokinetic models can include second-order kinetics to describe the chelation chemical reaction. The radiation dose to the animal is also calculated using S quantities specific for the animal, although the tissue weighting factors used to calculate the effective dose are those for the human.

MeSH terms

  • Algorithms
  • Animals
  • Chelating Agents / chemistry
  • Chelating Agents / pharmacokinetics*
  • Chelating Agents / therapeutic use
  • Computer Simulation
  • Decontamination / methods
  • Metabolic Clearance Rate
  • Models, Biological*
  • Organ Specificity
  • Radiation Dosage
  • Radiation Injuries, Experimental / metabolism*
  • Radiation Injuries, Experimental / prevention & control
  • Radiation-Protective Agents / chemistry
  • Radiation-Protective Agents / pharmacokinetics*
  • Radiation-Protective Agents / therapeutic use
  • Radioisotopes / chemistry
  • Radioisotopes / pharmacokinetics*
  • Rats
  • Software*
  • Tissue Distribution

Substances

  • Chelating Agents
  • Radiation-Protective Agents
  • Radioisotopes