Antimicrobial activity of geranium oil against clinical strains of Staphylococcus aureus

Molecules. 2012 Aug 28;17(9):10276-91. doi: 10.3390/molecules170910276.


The aim of this work was to investigate the antibacterial properties of geranium oil obtained from Pelargonium graveolens Ait. (family Geraniaceae), against one standard S. aureus strain ATCC 433000 and seventy clinical S. aureus strains. The agar dilution method was used for assessment of bacterial growth inhibition at various concentrations of geranium oil. Susceptibility testing of the clinical strains to antibiotics was carried out using the disk-diffusion and E-test methods. The results of our experiment showed that the oil from P. graveolens has strong activity against all of the clinical S. aureus isolates-including multidrug resistant strains, MRSA strains and MLS(B)-positive strains-exhibiting MIC values of 0.25-2.50 μL/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Drug Resistance, Bacterial / drug effects
  • Geranium / chemistry*
  • Humans
  • Microbial Sensitivity Tests
  • Pelargonium / chemistry*
  • Plant Oils / chemistry
  • Plant Oils / pharmacology*
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / growth & development


  • Anti-Bacterial Agents
  • Plant Oils