A bigger picture: classical cadherins and the dynamic actin cytoskeleton

Nat Rev Mol Cell Biol. 2012 Oct;13(10):673-9. doi: 10.1038/nrm3431. Epub 2012 Aug 30.


Classical cadherin adhesion receptors influence tissue integrity in health and disease. Their biological function is intimately linked to the actin cytoskeleton. To date, research has largely focused on identifying the molecular mechanisms that physically couple cadherin to cortical actin filaments. However, the junctional cytoskeleton is dynamic. Recent developments in understanding how filament dynamics and organization in the junctional cytoskeleton are controlled provide new insights into how the actin cytoskeleton regulates cadherin junctions in health and disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin Cytoskeleton / metabolism*
  • Actin Cytoskeleton / ultrastructure
  • Animals
  • Binding Sites
  • Cadherins / metabolism*
  • Cell Adhesion*
  • Protein Binding


  • Cadherins