Virology of hepatitis D virus

Semin Liver Dis. 2012 Aug;32(3):195-200. doi: 10.1055/s-0032-1323623. Epub 2012 Aug 29.


Although much of the current understanding of the replication of hepatitis D virus (HDV) has been gained from ex vivo rather than in vivo studies, many seemingly unique aspects have been discovered. These include the ultra-small size and circular conformation of the RNA genome, the presence on the viral RNAs of two ribozymes, the role of RNA-directed RNA transcription by redirection of host enzymes, the requirement of site-specific, posttranscriptional RNA-editing, and more. This review addresses recent insights, remaining controversies, and just plain deficits in our understanding of HDV replication.

Publication types

  • Review

MeSH terms

  • Hepatitis B virus / metabolism*
  • Hepatitis D / virology*
  • Hepatitis Delta Virus / genetics*
  • Hepatitis Delta Virus / immunology
  • Hepatitis Delta Virus / physiology*
  • Hepatitis delta Antigens
  • Humans
  • RNA, Viral / genetics*
  • RNA, Viral / metabolism
  • Viral Proteins / biosynthesis*
  • Virion
  • Virus Attachment
  • Virus Replication


  • Hepatitis delta Antigens
  • RNA, Viral
  • Viral Proteins
  • hepatitis delta virus large antigen