No association between genetic polymorphisms of the NDUFS7 gene and schizophrenia in Han Chinese

Psychiatr Genet. 2013 Feb;23(1):29-32. doi: 10.1097/YPG.0b013e32835862c5.

Abstract

Accumulating evidence suggests that mitochondrial dysfunction contributes toward the pathogenesis of psychiatric diseases. NADH dehydrogenase Fe-S protein 7 (NDUFS7), a subunit of respiratory chain complex I, has been reported recently to be associated with bipolar disorder. To test whether this gene can confer a wide variety of psychiatric disorders, we carried out a case-control association analysis of three tagging single-nucleotide polymorphisms (rs2074896, rs2074897, and rs2074898) in the NDUFS7 gene by sequencing 330 Han Chinese patients with schizophrenia and 330 well-matched healthy controls. We found no significant difference in the frequency distributions of alleles, genotypes, and haplotypes between the cases and the controls, indicating no active role of this gene in schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Asians / genetics*
  • Child
  • China
  • Ethnicity / genetics*
  • Female
  • Gene Frequency / genetics
  • Genetic Association Studies*
  • Genetic Predisposition to Disease*
  • Haplotypes / genetics
  • Humans
  • Linkage Disequilibrium / genetics
  • Male
  • Middle Aged
  • NADH Dehydrogenase / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Schizophrenia / genetics*
  • Young Adult

Substances

  • NADH Dehydrogenase
  • NDUFS7 protein, human