Addition of aripiprazole to the clozapine may be useful in reducing anxiety in treatment-resistant schizophrenia

Case Rep Psychiatry. 2011:2011:846489. doi: 10.1155/2011/846489. Epub 2011 Sep 14.


There exist many case reports and studies on the antipsychotic augmentation by aripirazole in partial responders to clozapine, the most seem to be finding a slight difference in the PANSS and CGI scores after the aripirazole addition. The results of our report are compatible with those of other studies but, we have found a considerable antianxiety action in both of the cases. The 5HT1A agonism of aripirazole could be hypothesized as mechanism contributing to this effect.

Publication types

  • Case Reports