Periorbital area rejuvenation using carbon dioxide therapy

J Cosmet Dermatol. 2012 Sep;11(3):223-8. doi: 10.1111/j.1473-2165.2012.00633.x.


Background: Different conservative and surgical approaches are used for periorbital region rejuvenation, but none of them is effective in the treatment of the medial third of the lower eyelid.

Objective: The present study is designed to assess the effectiveness of carboxytherapy in the treatment of wrinkles on the median and medial region of the lower eyelid and dark circles around the eyes.

Methods and materials: From January 2008 to December 2010, 90 patients with moderate to severe periorbital wrinkles and/or dark circles underwent subcutaneous injections of CO(2) once a week for 7 weeks. Patients were assessed before and 2 months after the treatment through photographic documentation and the compilation of visual analog scales.

Results: At the end of the study period, patients reported a reduction of facial fine lines and wrinkles as well as a decrease in periorbital hyperpigmentation. A few side effects were observed but they were all transient and did not require discontinuation of treatment.

Conclusion: Carbon dioxide therapy results as an effective noninvasive modality for the rejuvenation of the periorbital area.

MeSH terms

  • Adult
  • Aged
  • Carbon Dioxide / adverse effects
  • Carbon Dioxide / therapeutic use*
  • Ecchymosis / chemically induced
  • Edema / chemically induced
  • Eye / drug effects*
  • Eyelids / drug effects
  • Female
  • Humans
  • Hyperpigmentation / drug therapy
  • Injections, Subcutaneous
  • Male
  • Middle Aged
  • Photography
  • Rejuvenation*
  • Skin Aging / drug effects*


  • Carbon Dioxide