The belly rules the nose: feeding state-dependent modulation of peripheral chemosensory responses

Curr Opin Neurobiol. 2013 Feb;23(1):68-75. doi: 10.1016/j.conb.2012.08.001. Epub 2012 Aug 29.


Feeding history and the presence of food dramatically alter chemosensory behaviors. Recent results indicate that internal nutritional state can gate peripheral gustatory and olfactory sensory responses to affect behavior. Focusing primarily on recent work in C. elegans and Drosophila, I describe the neuromodulatory mechanisms that translate feeding state information into changes in chemosensory neuron response properties and behavioral output.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Chemoreceptor Cells / physiology
  • Feeding Behavior / physiology*
  • Signal Transduction / physiology*
  • Smell / physiology
  • Taste / physiology