Singles engage the RNA interference pathway

Beverly L Davidson; Alex Mas Monteys

doi:10.1016/j.cell.2012.08.008

Singles engage the RNA interference pathway

Cell. 2012 Aug 31;150(5):873-5. doi: 10.1016/j.cell.2012.08.008.

Authors

Beverly L Davidson, Alex Mas Monteys

PMID: 22939614
DOI: 10.1016/j.cell.2012.08.008

Abstract

Single-stranded RNAs interact with components of the RNA interference pathway to reduce the expression of target mRNAs. Now, Lima et al. and Yu et al. show that, with extensive chemical modifications, small single-stranded RNAs can robustly induce gene silencing with efficacy similar to their double-stranded counterparts.

Publication types

Comment
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Abstract

Publication types

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