LIS1 clamps dynein to the microtubule

Cell. 2012 Aug 31;150(5):877-9. doi: 10.1016/j.cell.2012.08.010.


Cytoplasmic dynein is a motor essential for numerous mechanical processes in eukaryotic cells. How its activity is regulated is largely unknown. By using a combination of approaches including single-molecule biophysics and electron microscopy, Huang et al. in this issue uncover the regulatory mechanism by which LIS1 controls the activity of cytoplasmic dynein.

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