Recent advances in bone tissue engineering scaffolds

Trends Biotechnol. 2012 Oct;30(10):546-54. doi: 10.1016/j.tibtech.2012.07.005. Epub 2012 Aug 30.


Bone disorders are of significant concern due to increase in the median age of our population. Traditionally, bone grafts have been used to restore damaged bone. Synthetic biomaterials are now being used as bone graft substitutes. These biomaterials were initially selected for structural restoration based on their biomechanical properties. Later scaffolds were engineered to be bioactive or bioresorbable to enhance tissue growth. Now scaffolds are designed to induce bone formation and vascularization. These scaffolds are often porous, made of biodegradable materials that harbor different growth factors, drugs, genes, or stem cells. In this review, we highlight recent advances in bone scaffolds and discuss aspects that still need to be improved.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Biotechnology / methods
  • Biotechnology / trends
  • Bone Regeneration
  • Bone and Bones*
  • Humans
  • Osteogenesis
  • Tissue Engineering / methods*
  • Tissue Scaffolds*