Curcumin Ameloriates Heat Stress via Inhibition of Oxidative Stress and Modulation of Nrf2/HO-1 Pathway in Quail

Food Chem Toxicol. 2012 Nov;50(11):4035-41. doi: 10.1016/j.fct.2012.08.029. Epub 2012 Aug 23.

Abstract

Curcumin, a natural polyphenol in the spice turmeric, exhibits antioxidant and antiinflammatory properties. This study was conducted to elucidate the action mode of curcumin alleviation of oxidative stress in heat-stressed quail. A total of 180 birds (10 d old) were assigned randomly to be reared at either 22°C (Thermoneutral) or 34°C (Heat stress) for 8 h/d (0900-1700) until the age of 42 d. Birds in both environments were randomly fed 1 of 3 diets: basal diet and basal diet added with 0, 200 or 400 mg of curcumin per kg of diet. Each of the 2×3 factorially arranged experimental groups was replicated in 10 cages, each containing three birds. In response to increasing supplemental curcumin level, there were linear increases in cumulative feed intake, final body weight, and weight gain, and nuclear factor erythroid 2-related factor two level and heme oxygenase one level; linear decreases in feed efficiency, serum, muscle and liver malondialdehyde level, respectively and inflammatory transcription factor, nuclear factor-κB and heat shock proteins 70 level (P<0.0001 for all). The results indicated that curcumin alleviates oxidative stress through modulating the hepatic nuclear transcription factors and heat shock proteins 70 in heat-stressed quails.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Feed
  • Animals
  • Antioxidants / pharmacology*
  • Body Weight / drug effects
  • Catalase / metabolism
  • Curcumin / pharmacology*
  • Dietary Supplements
  • Eating / drug effects
  • Glutathione Peroxidase / metabolism
  • HSP70 Heat-Shock Proteins / metabolism
  • Heat-Shock Response / drug effects*
  • Heat-Shock Response / physiology
  • Heme Oxygenase-1 / metabolism*
  • Liver / drug effects
  • Liver / metabolism
  • Malondialdehyde / metabolism
  • NF-E2-Related Factor 2 / metabolism*
  • NF-kappa B / metabolism
  • Oxidative Stress / drug effects*
  • Quail
  • Superoxide Dismutase / metabolism
  • Weight Gain

Substances

  • Antioxidants
  • HSP70 Heat-Shock Proteins
  • NF-E2-Related Factor 2
  • NF-kappa B
  • Malondialdehyde
  • Catalase
  • Glutathione Peroxidase
  • Heme Oxygenase-1
  • Superoxide Dismutase
  • Curcumin