miRNA_Targets: a database for miRNA target predictions in coding and non-coding regions of mRNAs

Genomics. 2012 Dec;100(6):352-6. doi: 10.1016/j.ygeno.2012.08.006. Epub 2012 Aug 25.

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that play a role in post-transcriptional regulation of gene expression in most eukaryotes. They help in fine-tuning gene expression by targeting messenger RNAs (mRNA). The interactions of miRNAs and mRNAs are sequence specific and computational tools have been developed to predict miRNA target sites on mRNAs, but miRNA research has been mainly focused on target sites within 3' untranslated regions (UTRs) of genes. There is a need for an easily accessible repository of genome wide full length mRNA - miRNA target predictions with versatile search capabilities and visualization tools. We have created a web accessible database of miRNA target predictions for human, mouse, cow, chicken, Zebra fish, fruit fly and Caenorhabditis elegans using two different target prediction algorithms, The database has target predictions for miRNA's on 5' UTRs, coding region and 3' UTRs of all mRNAs. This database can be freely accessed at http://mamsap.it.deakin.edu.au/mirna_targets/.

MeSH terms

  • Algorithms
  • Animals
  • Caenorhabditis elegans / genetics
  • Cattle
  • Chickens / genetics
  • Databases, Nucleic Acid*
  • Drosophila / genetics
  • Genome, Helminth
  • Genome, Human
  • Genome, Insect
  • Humans
  • Mice
  • MicroRNAs / chemistry*
  • MicroRNAs / metabolism
  • Open Reading Frames*
  • Sequence Analysis, RNA / methods
  • Untranslated Regions*
  • Zebrafish / genetics

Substances

  • MicroRNAs
  • Untranslated Regions