Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

Cheng-Shi Jiang; Lin-fu Liang; Yue-wei Guo

doi:10.1038/aps.2012.90

Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

Acta Pharmacol Sin. 2012 Oct;33(10):1217-45. doi: 10.1038/aps.2012.90. Epub 2012 Sep 3.

Authors

Cheng-Shi Jiang¹, Lin-fu Liang, Yue-wei Guo

Affiliation

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Abstract

This article provides an overview of approximately 300 secondary metabolites with inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), which were isolated from various natural sources or derived from synthetic process in the last decades. The structure-activity relationship and the selectivity of some compounds against other protein phosphatases were also discussed. Potential pharmaceutical applications of several PTP1B inhibitors were presented.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Diabetes Mellitus, Type 2 / drug therapy
Diabetes Mellitus, Type 2 / enzymology
Enzyme Inhibitors* / isolation & purification
Enzyme Inhibitors* / pharmacology
Enzyme Inhibitors* / therapeutic use
Humans
Molecular Structure
Obesity / drug therapy
Obesity / enzymology
Plant Preparations* / isolation & purification
Plant Preparations* / pharmacology
Plant Preparations* / therapeutic use
Plants, Medicinal / chemistry*
Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors*
Structure-Activity Relationship

Substances

Enzyme Inhibitors
Plant Preparations
PTPN1 protein, human
Protein Tyrosine Phosphatase, Non-Receptor Type 1