The genetic factors influencing the development of trichotillomania

J Genet. 2012 Aug;91(2):259-62. doi: 10.1007/s12041-011-0094-6.

Abstract

Trichotillomania (TTM), an obsessive-compulsive spectrum disorder (OCSD), is a psychiatric condition characterized by repetitive hair pulling. Evidence from family and twin studies suggest a heritable link of TTM. Functional polymorphisms in genes involved in neuronal pathways might influence the susceptibility to TTM. This review is an attempt to compile the genetic factors reported to modify the development of TTM.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antidepressive Agents / pharmacology
  • Antidepressive Agents / therapeutic use
  • Genetic Association Studies
  • Humans
  • Membrane Proteins / genetics
  • Nerve Tissue Proteins / genetics
  • Receptor, Serotonin, 5-HT2A / genetics
  • Receptors, Dopamine / genetics
  • SAP90-PSD95 Associated Proteins
  • Selective Serotonin Reuptake Inhibitors / pharmacology
  • Selective Serotonin Reuptake Inhibitors / therapeutic use
  • Serotonin Plasma Membrane Transport Proteins / genetics
  • Signal Transduction / genetics
  • Trichotillomania / drug therapy
  • Trichotillomania / genetics*
  • Twin Studies as Topic

Substances

  • Antidepressive Agents
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Dopamine
  • SAP90-PSD95 Associated Proteins
  • SLITRK1 protein, human
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin Uptake Inhibitors