Gastric cancer: Classification, histology and application of molecular pathology

J Gastrointest Oncol. 2012 Sep;3(3):251-61. doi: 10.3978/j.issn.2078-6891.2012.021.


Gastric cancer remains one of the deadly diseases with poor prognosis. New classification of gastric cancers based on histologic features, genotypes and molecular phenotypes helps better understand the characteristics of each subtype, and improve early diagnosis, prevention and treatment. The objective of this article is to review the new classification of gastric cancers and the up-to-date guidance in the application of molecular testing.

Keywords: CDH1; DPD; Gastric carcinoma; HER2; classification; histology; molecular pathology.