Mangosteen xanthones mitigate ovalbumin-induced airway inflammation in a mouse model of asthma

Food Chem Toxicol. 2012 Nov;50(11):4042-50. doi: 10.1016/j.fct.2012.08.037. Epub 2012 Aug 25.

Abstract

α- and γ-Mangostin, which are the major xanthones purified from a Mangosteen, Garcinia mangostana Linn., exhibit a wide range of anticancer, antioxidant, and anti-inflammatory activities. Here, we assessed their therapeutic effects in a mouse model of ovalbumin (OVA)-induced allergic asthma. Animals were treated with α- and γ-mangostins orally for 3 days at doses of 10 and 30 mg/kg daily, 1h before the OVA challenge. Administration of α- and γ-mangostins significantly reduced the major pathophysiological features of allergic asthma, including inflammatory cell recruitment into the airway, airway hyperresponsiveness (AHR), and increased levels of Th2 cytokines. In addition, α- and γ-mangostins attenuated the increases in phosphoinositide 3-kinase (PI3K) activity, phosphorylation of Akt, and NF-κB in nuclear protein extracts after OVA challenge. In conclusion, α- and γ-mangostin may have therapeutic potential for the treatment of allergic asthma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Anti-Asthmatic Agents / pharmacology*
  • Asthma / chemically induced
  • Asthma / drug therapy*
  • Asthma / metabolism
  • Asthma / physiopathology
  • Bronchial Hyperreactivity / drug therapy*
  • Bronchial Hyperreactivity / physiopathology
  • Bronchoalveolar Lavage Fluid / immunology
  • Disease Models, Animal
  • Female
  • Garcinia mangostana / chemistry*
  • Immunoglobulin E / blood
  • Interleukins / metabolism
  • Lung / drug effects
  • Lung / metabolism
  • Mice
  • Mice, Inbred BALB C
  • NF-kappa B / metabolism
  • Ovalbumin / toxicity
  • PTEN Phosphohydrolase / metabolism
  • Phosphatidylinositol 3-Kinases / metabolism
  • Proto-Oncogene Proteins c-akt / metabolism
  • Transforming Growth Factor beta1 / metabolism
  • Xanthones / pharmacology*

Substances

  • Anti-Asthmatic Agents
  • Interleukins
  • NF-kappa B
  • Transforming Growth Factor beta1
  • Xanthones
  • gamma-mangostin
  • Immunoglobulin E
  • Ovalbumin
  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins c-akt
  • PTEN Phosphohydrolase
  • Pten protein, mouse
  • mangostin