Wnt signaling in myogenesis

Trends Cell Biol. 2012 Nov;22(11):602-9. doi: 10.1016/j.tcb.2012.07.008. Epub 2012 Aug 31.


The formation of skeletal muscle is a tightly regulated process that is critically modulated by Wnt signaling. Myogenesis is dependent on the precise and dynamic integration of multiple Wnt signals allowing self-renewal and progression of muscle precursors in the myogenic lineage. Dysregulation of Wnt signaling can lead to severe developmental defects and perturbation of muscle homeostasis. Recent work has revealed novel roles for the non-canonical planar cell polarity (PCP) and AKT/mTOR pathways in mediating the effects of Wnt on skeletal muscle. In this review, we discuss the role of Wnt signaling in myogenesis and in regulating the homeostasis of adult muscle.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Heart / embryology
  • Humans
  • Muscle Development*
  • Myocardium / metabolism
  • Signal Transduction*
  • Wnt Proteins / metabolism


  • Wnt Proteins