Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 22 (5), 1051-9

Design and Analysis Issues of Multiregional Clinical Trials With Different Regional Primary Endpoints

Affiliations
Review

Design and Analysis Issues of Multiregional Clinical Trials With Different Regional Primary Endpoints

Hsiao-Hui Tsou et al. J Biopharm Stat.

Abstract

One of the challenges of multiregional drug development program is to design and analyze a multiple regional clinical trial with the objective being to satisfy different regional requirements on primary endpoints. Considered in this article is a multiregional clinical trial (MRCT) designed to test for two primary endpoints. Data of a regular fixed-size well-controlled parallel arm trial are used to test for two null hypotheses in terms of two distinct yet correlated endpoints. The two hypotheses may be tested sequentially or simultaneously. Depending on the structure of the hypotheses to be tested and the understanding of type I error rate control, various scenarios of type I error rate adjustments may be applied. Furthermore, for the objective of getting approval from regional authorities for different primary endpoints, various sample size and power determinations may be applied. In this article, comparisons of different approaches are discussed systematically.

Similar articles

See all similar articles

Cited by 1 PubMed Central articles

  • Multi-regional Clinical Trials and Global Drug Development
    P Shenoy. Perspect Clin Res 7 (2), 62-7. PMID 27141471. - Review
    Drug development has been globalized, and multi-regional clinical trial (MRCT) for regulatory submission has widely been conducted by many discovery based global pharmace …

MeSH terms

LinkOut - more resources

Feedback