Measles immunization in children with clinical reactions to egg protein

Am J Dis Child. 1990 Jan;144(1):33-5. doi: 10.1001/archpedi.1990.02150250039027.


Thirty-five egg-sensitive children who received measles immunization without adverse sequelae are described. Thirty-two of the children had a history of immediate hypersensitivity reactions to egg protein, including 22 who developed a generalized reaction after oral exposure to egg. There were also 3 highly allergic children, with immediate hypersensitivity reactions to other food, who, despite having never been exposed to egg, developed large skin prick test wheals to egg white. Measles vaccine was given to all children without prior vaccine skin testing. There were no adverse reactions. It is suggested that measles vaccine can be given to children with a history of generalized or localized urticaria/angioedema on exposure to egg protein without prior skin testing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child, Preschool
  • Egg Proteins, Dietary / adverse effects*
  • Egg White / adverse effects
  • Egg Yolk / adverse effects
  • Female
  • Food Hypersensitivity / immunology*
  • Humans
  • Hypersensitivity, Immediate / immunology*
  • Infant
  • Male
  • Measles Vaccine / adverse effects*
  • Milk Proteins / adverse effects
  • Ovalbumin / adverse effects
  • Skin Tests


  • Egg Proteins, Dietary
  • Measles Vaccine
  • Milk Proteins
  • Ovalbumin