Proinflammatory cytokines in serum and cerebrospinal fluid of CIDP patients

Neurol Res. 2012 Nov;34(9):842-6. doi: 10.1179/1743132812Y.0000000074. Epub 2012 Sep 4.


Introduction: Little is known about the role of cytokines in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Interleukin (IL)-12 and IL-15 are the major growth and differentiation factors for Th-1 cells and IL-17 is a marker of Th-17 cell expansion and activation, a high proinflammatory new subset of T cells that induce severe autoimmunity.

Patients and methods: We measured by enzyme-like immunosorbent assay serum and cerebrospinal fluid (CSF) levels of IL-15, IL-12, and IL-17 in 24 patients with CIDP and 12 patients with other non-inflammatory neurological disorders and serum levels in 16 healthy subjects.

Results: We found a positive association of CSF IL-12 (P = 0·012) with CIDP presence (P<0·001).

Conclusions: Our findings suggest that IL-12 may be involved as potential marker of immune activation in CIDP. The increase in its levels in CSF may be a marker of initiation of Th-1 cell-mediated immunity.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cytokines / blood*
  • Cytokines / cerebrospinal fluid*
  • Disability Evaluation
  • Encephalitis / blood
  • Encephalitis / cerebrospinal fluid
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Male
  • Middle Aged
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / blood*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / cerebrospinal fluid*


  • Cytokines