Peripheral QCT sector analysis reveals early exercise-induced increases in tibial bone mineral density

J Musculoskelet Neuronal Interact. 2012 Sep;12(3):155-64.


Objectives: The purpose of this controlled trial was to determine whether subtle changes in mineralization and geometry of the tibia were evident following short term exercise interventions.

Methods: Fifty-seven female volunteers (age 20.1±1.6) were randomized to one of four, 13-week training groups: sedentary control, resistance training, aerobic training, or combined aerobic-resistance. A pQCT image analysis software was developed and used to analyze images taken at sites 4%, 38% and 66% from the distal tibia at baseline and at completion of training. Parameters of bone mineral density, geometry and strength were determined for the entire scan cross-section and for each of six 60° polar sectors. Repeated-measures ANOVA and Fisher's LSD post hoc tests analyzed the effects of training over time.

Results: Trabecular density (TrDn) at the 4% site increased from 279.8±37.1 to 283.1±36.0 mg/cm(3) in the aerobic group, and from 285.1±24.6 to 287.5±22.9 mg/cm(3) in the combined group over the study period (P≤0.001). Regional sector analyses revealed that impact exercises resulted in localized changes to the medial aspect of the tibia. Small increases in total bone area were observed in the diaphysis (38% site) (P<0.05).

Conclusions: Subtle, regional increases in trabecular density may be an early measurable manifestation of bone quality changes.

Publication types

  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Bone Density / physiology*
  • Exercise / physiology*
  • Female
  • Humans
  • Image Interpretation, Computer-Assisted
  • Tibia / diagnostic imaging*
  • Tomography, X-Ray Computed
  • Young Adult