Dancing partners at the synapse: auxiliary subunits that shape kainate receptor function

Nat Rev Neurosci. 2012 Oct;13(10):675-86. doi: 10.1038/nrn3335.


Kainate receptors are a family of ionotropic glutamate receptors whose physiological roles differ from those of other subtypes of glutamate receptors in that they predominantly serve as modulators, rather than mediators, of synaptic transmission. Neuronal kainate receptors exhibit unusually slow kinetic properties that have been difficult to reconcile with the behaviour of recombinant kainate receptors. Recently, however, the neuropilin and tolloid-like 1 (NETO1) and NETO2 proteins were identified as auxiliary kainate receptor subunits that shape both the biophysical properties and synaptic localization of these receptors.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Gene Targeting / methods
  • Humans
  • Membrane Proteins / physiology*
  • Protein Subunits / physiology*
  • Receptors, Kainic Acid / physiology*
  • Receptors, N-Methyl-D-Aspartate
  • Synapses / physiology*


  • Membrane Proteins
  • NETO1 protein, human
  • Protein Subunits
  • Receptors, Kainic Acid
  • Receptors, N-Methyl-D-Aspartate