The effects of angiotensin-converting enzyme inhibitors on peritoneal protein loss and solute transport in peritoneal dialysis patients

Clinics (Sao Paulo). 2012 Aug;67(8):877-83. doi: 10.6061/clinics/2012(08)04.


Objective: The objective of this study was to examine the effects of angiotensin-converting enzyme inhibitors on peritoneal membrane transport, peritoneal protein loss, and proteinuria in peritoneal dialysis patients.

Methods: Fifty-four peritoneal dialysis patients were included in the study. The patients were divided into two groups. Group 1 (n = 34) was treated with angiotensin-converting enzyme inhibitors. Group 2 (n = 20) did not receive any antihypertensive drugs during the entire follow-up. Eleven patients were excluded from the study thereafter. Thus, a total of 30 patients in Group 1 and 13 patients in Group 2 completed the study. We observed the patients for six months. Group 1 patients received maximal doses of angiotensin-converting enzyme inhibitors for six months. Parameters at the beginning of study and at the end of six months were evaluated.

Results: At the end of six months, total peritoneal protein loss in 24-hour dialysate effluent was significantly decreased in Group 1, whereas it was increased in Group 2. Compared to the baseline level, peritoneal albumin loss in 24-hour dialysate effluent and 4-hour D/P creatinine were significantly increased in Group 2 but were not significantly changed in Group 1. A covariance analysis between the groups revealed a significant difference only in the decreased amount of total protein loss in 24-hour dialysate. Proteinuria was decreased significantly in Group 1.

Conclusion: This study suggests that angiotensin-converting enzyme inhibitors reduce peritoneal protein loss and small-solute transport and effectively protect peritoneal membrane transport in peritoneal dialysis patients.

MeSH terms

  • Adolescent
  • Adult
  • Albumins / analysis
  • Albumins / metabolism*
  • Angiotensin-Converting Enzyme Inhibitors / pharmacology*
  • Biological Transport
  • Epidemiologic Methods
  • Female
  • Humans
  • Male
  • Middle Aged
  • Peritoneal Dialysis / adverse effects*
  • Peritoneum / metabolism*
  • Proteins / metabolism
  • Time Factors
  • Treatment Outcome
  • Young Adult


  • Albumins
  • Angiotensin-Converting Enzyme Inhibitors
  • Proteins