Abstract
Two new unusual 6-furanoflavones, hoslunfuranine (5) and 5-O-methylhoslunfuranine (6), were isolated from the leaves of Hoslundia opposita Vahl.. Four known methylpyranoflavonic analogues [hosloppin (1), hoslundin (2), 5-O-methylhoslundin (3), oppositin (4)], all specific of the species, were also obtained. Their structures were established on the basis of their spectroscopic data. In vitro cytotoxic, trypanocidal, and leishmanicidal activities of compounds 1 and 3 to 6 were evaluated. Compounds 4 and 6 exhibited leishmanicidal potential in the micromolar range.
Georg Thieme Verlag KG Stuttgart · New York.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / isolation & purification
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Antiprotozoal Agents / pharmacology
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Drug Screening Assays, Antitumor
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Flavones / chemistry
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Flavones / isolation & purification
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Flavones / pharmacology*
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Humans
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KB Cells
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Lamiaceae / chemistry*
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Leishmania donovani / drug effects
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Magnetic Resonance Spectroscopy
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Parasitic Sensitivity Tests
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Plant Leaves / chemistry*
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Pyrones / chemistry
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Pyrones / isolation & purification
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Pyrones / pharmacology*
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Trypanosoma brucei brucei / drug effects
Substances
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5-O-methylhoslunfuranine
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Antineoplastic Agents, Phytogenic
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Antiprotozoal Agents
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Flavones
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Pyrones
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hosloppin
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oppositin