Selective silencing of cell communication influences anteroposterior pattern formation in C. elegans

Cell. 1990 Jan 12;60(1):123-31. doi: 10.1016/0092-8674(90)90722-q.


In C. elegans males, laterally located V cells generate a simple pattern of anterior alae (cuticular ridges) and posterior rays (mating sensilla). We have found that this pattern is generated, at least in part, by the selective interruption of cell-cell interactions. In anterior V cells, lineages leading to the production of alae are induced by cell interactions. These cell interactions are inhibited in specific posterior V cells by the activity of the gene pal-1, which allows these cells to generate rays instead of alae. The activities of cell signals and pal-1 appear to influence V cell fates by determining the state of a developmental switch that involves two homeotic genes, lin-22 and mab-5.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Animals
  • Caenorhabditis / genetics
  • Caenorhabditis / growth & development
  • Caenorhabditis / physiology*
  • Cell Communication*
  • Cell Division
  • Female
  • Lasers
  • Male
  • Mutation