Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study

Int Braz J Urol. Jul-Aug 2012;38(4):512-8. doi: 10.1590/s1677-55382012000400011.

Abstract

Introduction: Male testosterone deficiency is associated with bad sexual function and quality of life (QoL). The aim of this study was to determine whether a daily dose of 25 mg clomiphene citrate (CC) is effective in stimulating the endogenous testosterone production pathway and to address the applicability of this medication as a therapeutic option for symptomatic hypogonadism.

Materials and methods: This was a prospective study. Men with low sexual desire and testosterone levels (T) below 400 ng/dL were selected to receive CC. Blood samples were obtained to determine baseline measurements of serum T, estradiol, LH, lipid profile and fasting plasma glucose. Each patient was treated with a daily dose of 25 mg CC for at least 3 months. Patients were asked if they experienced any side effects related to the use of CC and if they experienced any improvement in their sexual profile. Paired samples T-test was utilized to analyze responses to therapy.

Results: Our cohort consisted of 125 men with hypogonadism and low libido. Mean age was 62 years (± 11.1 years). Serum T levels ranged from 309 ng/dL (baseline, mean value) to 642 ng/dL (3 months after CC initiation, mean value) (p < 0.001). Serum cholesterol levels ranged from 197 to 186 mg/dL (p = 0.003). There were no statistically significant differences when comparing pre and post-treatment HDL-Cholesterol, triglycerides, fasting plasma glucose and prolactin. All men reported improvements in the post-treatment QoL scores. No serious adverse events were recorded.

Conclusions: The CC was effective in stimulating the endogenous production of testosterone. A lower level of total cholesterol was verified after three months of treatment. This medication should be considered as a therapeutic option for some patients with symptomatic male testosterone deficiency.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Clomiphene / administration & dosage*
  • Epidemiologic Methods
  • Estrogen Antagonists / administration & dosage*
  • Humans
  • Hypogonadism / drug therapy*
  • Luminescence
  • Male
  • Middle Aged
  • Quality of Life
  • Testosterone / blood
  • Testosterone / deficiency*
  • Testosterone / metabolism
  • Time Factors
  • Treatment Outcome

Substances

  • Estrogen Antagonists
  • Clomiphene
  • Testosterone