Molecular signature in HCV-positive lymphomas

Clin Dev Immunol. 2012;2012:623465. doi: 10.1155/2012/623465. Epub 2012 Aug 16.

Abstract

Hepatitis C virus (HCV) is a positive, single-stranded RNA virus, which has been associated to different subtypes of B-cell non-Hodgkin lymphoma (B-NHL). Cumulative evidence suggests an HCV-related antigen driven process in the B-NHL development. The underlying molecular signature associated to HCV-related B-NHL has to date remained obscure. In this review, we discuss the recent developments in this field with a special mention to different sets of genes whose expression is associated with BCR coupled to Blys signaling which in turn was found to be linked to B-cell maturation stages and NF-κb transcription factor. Even if recent progress on HCV-B-NHL signature has been made, the precise relationship between HCV and lymphoma development and phenotype signature remain to be clarified.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • B-Cell Activating Factor / metabolism
  • B-Lymphocytes / immunology
  • B-Lymphocytes / metabolism
  • Hepacivirus / genetics
  • Hepacivirus / immunology
  • Hepacivirus / physiology
  • Hepatitis C Antigens
  • Hepatitis C, Chronic* / immunology
  • Hepatitis C, Chronic* / metabolism
  • Hepatitis C, Chronic* / virology
  • Humans
  • Lymphoma, B-Cell / genetics*
  • Lymphoma, B-Cell / metabolism
  • Lymphoma, B-Cell / virology*
  • NF-kappa B / metabolism
  • Receptors, Antigen, B-Cell / immunology
  • Receptors, Antigen, B-Cell / metabolism
  • Signal Transduction

Substances

  • B-Cell Activating Factor
  • Hepatitis C Antigens
  • NF-kappa B
  • Receptors, Antigen, B-Cell
  • TNFSF13B protein, human