Total synthesis of the proposed structure of mycosporulone: structural revision and an unexpected retro-aldol/aldol reaction
- PMID: 22954011
- DOI: 10.1021/ol302234a
Total synthesis of the proposed structure of mycosporulone: structural revision and an unexpected retro-aldol/aldol reaction
Abstract
The proposed structure of the fungal metabolite, mycosporulone 1, was prepared starting from the cyclohexenone ester 11 and the D-(R)-glyceraldehyde acetonide 12. The spectroscopic data for both 1 and its C2 epimer 1a did not match those reported for the natural product. A revised structure 29 for mycosporulone is proposed.
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