Volume-limited and volume-targeted ventilation

Clin Perinatol. 2012 Sep;39(3):513-23. doi: 10.1016/j.clp.2012.06.016.


This article shows that volume-targeted ventilation is physiologically more logical than pressure-limited ventilation, and is associated with a reduced risk of pneumothorax, hypocarbia, duration of ventilation, death or bronchopulmonary dysplasia, and severe intraventricular hemorrhage. Therefore, it should now be adopted as the main mode for mechanical ventilation of preterm neonates.

Publication types

  • Review

MeSH terms

  • Carbon Dioxide / blood
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Lung Compliance
  • Lung Volume Measurements
  • Respiration, Artificial / adverse effects
  • Respiration, Artificial / methods*
  • Respiratory Distress Syndrome, Newborn / physiopathology
  • Respiratory Distress Syndrome, Newborn / therapy*
  • Tidal Volume / physiology


  • Carbon Dioxide