5-Fluorouracil neurotoxicity

Gynecol Oncol. 1990 Jan;36(1):152-4. doi: 10.1016/0090-8258(90)90127-7.


Two cases of 5-fluorouracil-induced neurotoxicity from the University of North Carolina are presented. 5-Fluorouracil metabolism is briefly discussed with reference to possible mechanisms for the neurotoxicity. A possible role for thiamine supplementation in the prevention of this unusual complication is supported by our experience.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Carcinoma, Squamous Cell / drug therapy
  • Female
  • Fluorouracil / adverse effects*
  • Fluorouracil / metabolism
  • Humans
  • Middle Aged
  • Nervous System Diseases / chemically induced*
  • Thiamine Deficiency / complications
  • Uterine Cervical Neoplasms / drug therapy


  • Fluorouracil