SAPIN: a framework for the structural analysis of protein interaction networks

Bioinformatics. 2012 Nov 15;28(22):2998-9. doi: 10.1093/bioinformatics/bts539. Epub 2012 Sep 6.


Summary: Protein interaction networks are widely used to depict the relationships between proteins. These networks often lack the information on physical binary interactions, and they do not inform whether there is incompatibility of structure between binding partners. Here, we introduce SAPIN, a framework dedicated to the structural analysis of protein interaction networks. SAPIN first identifies the protein parts that could be involved in the interaction and provides template structures. Next, SAPIN performs structural superimpositions to identify compatible and mutually exclusive interactions. Finally, the results are displayed using Cytoscape Web.

Availability: The SAPIN server is available at

Contact: or

Supplementary information: Supplementary data are available at Bioinformatics Online.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Protein Interaction Mapping
  • Protein Interaction Maps*
  • Proteins / chemistry*
  • Proteins / metabolism*
  • Sequence Analysis, Protein
  • Software*


  • Proteins