Myositis autoantibodies

Curr Opin Rheumatol. 2012 Nov;24(6):602-8. doi: 10.1097/BOR.0b013e328358bd85.


Purpose of review: To review recent advances in our understanding of autoantibodies associated with dermatomyositis and the autoimmune necrotizing myopathies.

Recent findings: Autoantibodies preferentially associated with dermatomyositis include those recognizing Mi-2, MDA5, TIF1γ, and NXP-2. Each of these is associated with a distinct clinical phenotype. Autoantibodies found in patients with autoimmune necrotizing myopathies recognize signal recognition particle and 3-hydroxy-3-methylglutaryl-coenzime A reductase (HMG-CoA) reductase. The latter are found in patients with statin-associated autoimmune muscle disease.

Summary: As these are helpful both diagnostically and prognostically, a rheumatologist should be familiar with autoantibodies found in patients with dermatomyositis and the autoimmune necrotizing myopathies.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adenosine Triphosphatases / immunology
  • Autoantibodies / blood*
  • Autoantigens / immunology
  • Autoimmune Diseases / blood
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / pathology
  • Autoimmunity*
  • DEAD-box RNA Helicases / immunology
  • DNA-Binding Proteins / immunology
  • Dermatomyositis / chemically induced
  • Dermatomyositis / immunology*
  • Dermatomyositis / pathology
  • Humans
  • Hydroxymethylglutaryl CoA Reductases / immunology
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects
  • Interferon-Induced Helicase, IFIH1
  • Mi-2 Nucleosome Remodeling and Deacetylase Complex / immunology
  • Necrosis
  • Signal Recognition Particle / immunology
  • Transcription Factors / immunology


  • Autoantibodies
  • Autoantigens
  • CHD4 protein, human
  • DNA-Binding Proteins
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Signal Recognition Particle
  • TRIM33 protein, human
  • Transcription Factors
  • Hydroxymethylglutaryl CoA Reductases
  • Mi-2 Nucleosome Remodeling and Deacetylase Complex
  • Adenosine Triphosphatases
  • IFIH1 protein, human
  • MORC3 protein, human
  • DEAD-box RNA Helicases
  • Interferon-Induced Helicase, IFIH1