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Review
. 2012 Oct;12(10):721-8.
doi: 10.1038/nri3294. Epub 2012 Sep 7.

Unconventional Recognition of Peptides by T Cells and the Implications for Autoimmunity

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Review

Unconventional Recognition of Peptides by T Cells and the Implications for Autoimmunity

James F Mohan et al. Nat Rev Immunol. .

Abstract

The interaction of antigen-presenting cells with free peptides or a denatured protein can give rise to peptide-MHC class II complexes that are distinct from those generated after the processing of the whole protein. Such atypical peptide-MHC complexes can be recognized by unconventional 'type B' T cells that are not a component of the normal immune response to proteins. Importantly, these unconventional T cells can be found in the setting of autoimmunity. Here, we discuss unconventional peptide recognition by type B T cells and consider the implications for type 1 diabetes and other autoimmune diseases.

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