Bridging the gap between a TB drug and its target

Sci Transl Med. 2012 Sep 5;4(150):150fs33. doi: 10.1126/scitranslmed.3004816.


A promising new TB drug cocrystallized with its mycobacterial target provides a platform for structure-based design that will improve TB drug development (Neres et al.).

Publication types

  • Comment

MeSH terms

  • Antitubercular Agents / chemistry*
  • Antitubercular Agents / pharmacology*
  • Microbial Viability / drug effects*
  • Mycobacterium tuberculosis / drug effects*
  • Thiazines / chemistry*
  • Thiazines / pharmacology*


  • Antitubercular Agents
  • Thiazines