Effect of L-arginine Supplementation on Blood Pressure in Pregnant Women: A Meta-Analysis of Placebo-Controlled Trials

Hypertens Pregnancy. 2013;32(1):32-41. doi: 10.3109/10641955.2012.697952. Epub 2012 Sep 7.


Objective: A meta-analysis of placebo-controlled trials was conducted to evaluate the effect of L-arginine supplementation on blood pressure (BP) in pregnancy.

Methods: Trials were searched in PubMed, Embase, and Cochrane Library. A total of five trials were included in the meta-analysis.

Results: L-arginine supplementation exhibited a mean decrease of 3.07 mmHg (p = 0.004) for diastolic blood pressure and a mean increase of 1.23 weeks (p = 0.002) for gestation age at delivery in pregnancy, but did not reduce systolic BP (p = 0.19) as compared to placebo.

Conclusion: L-arginine supplementation had a significant effect of lowering diastolic blood pressure and prolonging gestation age in pregnancy.

Publication types

  • Meta-Analysis

MeSH terms

  • Arginine / pharmacology
  • Arginine / therapeutic use*
  • Blood Pressure / drug effects*
  • Controlled Clinical Trials as Topic
  • Dietary Supplements
  • Female
  • Gestational Age
  • Humans
  • Hypertension, Pregnancy-Induced / drug therapy*
  • Pregnancy


  • Arginine