Pain processing in the human nervous system: a selective review of nociceptive and biobehavioral pathways

Prim Care. 2012 Sep;39(3):561-71. doi: 10.1016/j.pop.2012.06.013. Epub 2012 Jul 24.

Abstract

This selective review discusses the psychobiological mediation of nociception and pain. Summarizing literature from physiology and neuroscience, first an overview of the neuroanatomic and neurochemical systems underpinning pain perception and modulation is provided. Second, findings from psychological science are used to elucidate cognitive, emotional, and behavioral factors central to the pain experience. This review has implications for clinical practice with patients suffering from chronic pain, and provides strong rationale for assessing and treating pain from a biopsychosocial perspective.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adaptation, Psychological
  • Affect
  • Autonomic Nervous System
  • Behavior Therapy / methods*
  • Chronic Disease
  • Cognition
  • Emotions
  • Humans
  • Low Back Pain / pathology*
  • Low Back Pain / psychology
  • Neuroanatomy
  • Neurobiology
  • Nociceptive Pain / pathology*
  • Nociceptive Pain / psychology
  • Perception
  • Stress, Psychological