Deterministic or stochastic choices in retinal neuron specification

Zhenqing Chen; Xin Li; Claude Desplan

doi:10.1016/j.neuron.2012.08.008

Deterministic or stochastic choices in retinal neuron specification

Neuron. 2012 Sep 6;75(5):739-42. doi: 10.1016/j.neuron.2012.08.008.

Authors

Zhenqing Chen¹, Xin Li, Claude Desplan

Affiliation

¹ Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA.

Abstract

There are two views on vertebrate retinogenesis: a deterministic model dependent on fixed lineages and a stochastic model in which choices of division modes and cell fates cannot be predicted. In this issue of Neuron, He et al. (2012) address this question in zebrafish using live imaging and mathematical modeling.

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