Synaptic energy use and supply

Neuron. 2012 Sep 6;75(5):762-77. doi: 10.1016/j.neuron.2012.08.019.


Neuronal computation is energetically expensive. Consequently, the brain's limited energy supply imposes constraints on its information processing capability. Most brain energy is used on synaptic transmission, making it important to understand how energy is provided to and used by synapses. We describe how information transmission through presynaptic terminals and postsynaptic spines is related to their energy consumption, assess which mechanisms normally ensure an adequate supply of ATP to these structures, consider the influence of synaptic plasticity and changing brain state on synaptic energy use, and explain how disruption of the energy supply to synapses leads to neuropathology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / metabolism*
  • Brain / physiology
  • Brain Chemistry / physiology*
  • Energy Metabolism / physiology*
  • Humans
  • Neuronal Plasticity / physiology*
  • Synaptic Transmission / physiology*