Estrone Sulfate and Dehydroepiandrosterone Sulfate Concentrations in Normal Subjects and Men With Cirrhosis

Steroids. 1979 Nov;34(5):563-73. doi: 10.1016/s0039-128x(79)80017-3.

Abstract

Circulation levels of estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHAS) have been measured in plasma using a radioimmunoassay for estrone and dehydroepiandrosterone following extraction and hydrolysis of the sulfate. The mean +/- SE concentrations of E1S and DHAS in normal men were 458 +/- 25 pg/ml and 1.45 +/- 0.19 micrograms/ml, respectively. In normal women the values for days 5-7 of the cycle were 880 +/- 117 pg/ml and 1.25 +/- 0.12 micrograms/ml which were not different than the values for days 20-22 of 1195 +/- 176 pg/ml and 1.58 +/- 0.29 micrograms/ml. The mean values in post-menopausal women were 250 +/- 33 pg/ml and 0.47 +/- 0.07 micrograms/ml, both lower than the values in young women. In a group of cirrhotic men the mean values were 325 +/- 55 pg/ml and 0.38 +/- 0.12 micrograms/ml, both significantly lower than the normal values. This suggests a defect in sulfurylation in men with hepatic cirrhosis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Dehydroepiandrosterone / analogs & derivatives*
  • Dehydroepiandrosterone / blood
  • Estrogens, Conjugated (USP) / blood*
  • Estrone / analogs & derivatives*
  • Estrone / blood
  • Female
  • Humans
  • Liver Cirrhosis / blood*
  • Male
  • Menopause
  • Middle Aged
  • Radioimmunoassay
  • Sulfuric Acids / blood

Substances

  • Estrogens, Conjugated (USP)
  • Sulfuric Acids
  • Estrone
  • Dehydroepiandrosterone
  • estrone sulfate