Long noncoding RNAs with snoRNA ends

Mol Cell. 2012 Oct 26;48(2):219-30. doi: 10.1016/j.molcel.2012.07.033. Epub 2012 Sep 6.


We describe the discovery of sno-lncRNAs, a class of nuclear-enriched intron-derived long noncoding RNAs (lncRNAs) that are processed on both ends by the snoRNA machinery. During exonucleolytic trimming, the sequences between the snoRNAs are not degraded, leading to the accumulation of lncRNAs flanked by snoRNA sequences but lacking 5' caps and 3' poly(A) tails. Such RNAs are widely expressed in cells and tissues and can be produced by either box C/D or box H/ACA snoRNAs. Importantly, the genomic region encoding one abundant class of sno-lncRNAs (15q11-q13) is specifically deleted in Prader-Willi Syndrome (PWS). The PWS region sno-lncRNAs do not colocalize with nucleoli or Cajal bodies, but rather accumulate near their sites of synthesis. These sno-lncRNAs associate strongly with Fox family splicing regulators and alter patterns of splicing. These results thus implicate a previously unannotated class of lncRNAs in the molecular pathogenesis of PWS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Base Sequence
  • Cell Line
  • Cell Nucleolus / genetics
  • Cell Nucleolus / metabolism
  • Coiled Bodies / genetics
  • Coiled Bodies / metabolism
  • Gene Expression Regulation
  • Humans
  • Introns
  • Molecular Sequence Data
  • Prader-Willi Syndrome* / genetics
  • Prader-Willi Syndrome* / metabolism
  • RNA Splicing / genetics*
  • RNA Splicing Factors
  • RNA, Long Noncoding* / genetics
  • RNA, Long Noncoding* / metabolism
  • RNA, Small Nucleolar* / genetics
  • RNA, Small Nucleolar* / metabolism
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism


  • RBFOX2 protein, human
  • RNA Splicing Factors
  • RNA, Long Noncoding
  • RNA, Small Nucleolar
  • RNA-Binding Proteins
  • Repressor Proteins

Associated data

  • GEO/GSE38541